Gaucher Disease: Forging a New Path to the Lysosome
نویسنده
چکیده
Most lysosomal proteins are tagged with a carbohydrate modification that allows their recognition and transport to the lysosome. In this issue, Reczek et al. (2007) identify a new pathway for protein sorting to the lysosome. They show that beta-glucocerebrosidase-the lysosomal enzyme defective in patients with Gaucher disease-is delivered to the lysosome through its interaction with the transmembrane protein LIMP-2.
منابع مشابه
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ورودعنوان ژورنال:
- Cell
دوره 131 شماره
صفحات -
تاریخ انتشار 2007